Martínez-Tellería A, Cano Serrano M E, Rufino Ruiz J
Servicio de Anestesiología, Hospital Virgen de las Nieves, Granada.
Rev Esp Anestesiol Reanim. 1999 Mar;46(3):106-10.
To evaluate the anesthetic efficacy of EMLA cream for alleviating pain associated with puncture and pressure in areas where venous catheters are normally inserted.
We performed a prospective, double blind study in 38 volunteers between 25 and 36 years of age, after obtaining informed consent. A 1.5 g dose of EMLA cream was applied to three sites on each patient: the back of the hand, the antecubital fossa and the side of the neck. Placebo cream with similar characteristics was applied to contralateral sites. Pain was evaluated on a visual analog scale (VAS, 0-10). Tactile sensitivity was assessed on a four-point scale (0 = no sensation; 1 = slight sensation; 2 = moderate, and 3 = strong). An analysis of variance study was performed to compare baseline scores to results over time, and placebo results to EMLA scores for each test site.
The assessment of response to puncture and pressure gradually decreased over time for the sites where EMLA cream was applied, but not for the areas where placebo was applied.
The efficacy of EMLA cream varies demonstrably depending on type of stimulus, site of application and time since application.
评估复方利多卡因乳膏对减轻静脉导管正常插入部位穿刺和按压相关疼痛的麻醉效果。
在获得知情同意后，我们对38名年龄在25至36岁之间的志愿者进行了一项前瞻性双盲研究。给每位患者的三个部位涂抹1.5克复方利多卡因乳膏：手背、肘前窝和颈部侧面。将具有相似特性的安慰剂乳膏涂抹于对侧部位。采用视觉模拟评分法（VAS，0 - 10）评估疼痛程度。采用四点量表（0 = 无感觉；1 = 轻微感觉；2 = 中度感觉；3 = 强烈感觉）评估触觉敏感性。进行方差分析研究，以比较每个测试部位的基线评分与随时间变化的结果，以及安慰剂结果与复方利多卡因乳膏的评分。
涂抹复方利多卡因乳膏的部位对穿刺和按压的反应评估随时间逐渐降低，但涂抹安慰剂的部位则不然。
复方利多卡因乳膏的疗效因刺激类型、涂抹部位和涂抹后时间的不同而有明显差异。
