Fetisova T V
Kardiologiia. 1976 Jun;16(6):89-93.
Forty-two dogs were subjected to studies of nitrogen-containing metabolites in the blood of the aorta, coronary sinus and in various parts of the heart under normal conditions and 1, 24 hours and 3 days following the induction of myocardial infarction. In normal dogs the myocardium usually retains from the in-flowing blood such components as urea, glutamine, RNA, non-organic phosphates, while the arterio-venous gradient of ammonium, DNA and nucleases is close to zero. The ligation of the coronary sinus is followed by a deceleration of urea formation in the liver, the amount of urea formation in the liver, the amount of urea in the arterial blood and myocardium decreases, the latter, instead of retaining it, throwing it out into the coronary sinus. Like in normal cases, in this pathology the heart muscle is capable of synthesizing urea from ammonium. The infarctized heart actively retains glutamine from blood using it in situ, and does not increase the secretion of free ammonium into the coronary sinus. The level of nucleic acids and the activity of the nucleases significantly increase in the diseased tissue, undergoing no important changes in the blood circulating in the cardiac vessels.
42只狗在正常情况下以及在诱导心肌梗死后1小时、24小时和3天，接受了对主动脉血、冠状窦血以及心脏各个部位含氮代谢物的研究。在正常狗中，心肌通常从流入的血液中保留尿素、谷氨酰胺、RNA、无机磷酸盐等成分，而铵、DNA和核酸酶的动静脉梯度接近零。结扎冠状窦后，肝脏中尿素生成减速，肝脏中尿素生成量、动脉血和心肌中的尿素量减少，心肌不再保留尿素，而是将其排入冠状窦。与正常情况一样，在这种病理状态下，心肌能够利用铵合成尿素。梗死的心脏积极地从血液中保留谷氨酰胺并在原位利用它，并且不会增加游离铵向冠状窦的分泌。患病组织中核酸水平和核酸酶活性显著增加，而在心脏血管中循环的血液中没有发生重要变化。
