Fetisova T V, Shiriakova L I
Kardiologiia. 1980 May;20(5):76-80.
Significant shifts were revealed in the content, disintegration, and synthesis of nucleic acids in the zone of the infarction and adjacent areas of the heart in experiments on 83 dogs. In the area of the necrosis, the total level and RNA transformation are reduced at the beginning but grow with the development of the reparative processes, whereas DNA metabolism is activated stably beginning with the 1st day of the reproduction of the pathological condition. Short-term changes in nuclein metabolism, similar to those in the zone of the infarction, occur in the adjacent areas. In myocardial infarction, in the initial stage of its development too, the heart does not secrete nucleic acids or polynucleases into the coronary sinus and their values in the serum are close to normal. Long-term activation of deoxyribonuclease in myocardial infarction is the cause of the stable increase in the blood of the products of DNA hydrolysis, which is recommended as a pathogenetically substantiated laboratory diagnostic test for this disease.
在对83只狗进行的实验中，梗死区及心脏相邻区域的核酸含量、分解和合成出现了显著变化。在坏死区域，核酸总量和RNA转化在开始时降低，但随着修复过程的发展而增加，而DNA代谢从病理状态重现的第一天起就稳定激活。相邻区域也出现了类似于梗死区的核蛋白代谢短期变化。在心肌梗死发展的初始阶段，心脏也不会将核酸或核酸酶分泌到冠状窦中，其血清值接近正常。心肌梗死中脱氧核糖核酸酶的长期激活是DNA水解产物血液中稳定增加的原因，这被推荐作为该病有病理依据的实验室诊断测试。
