Bensaid J, Rouffaud J, Blanc G
Arch Mal Coeur Vaiss. 1978 Sep;71(9):1044-52.
The association of idiopathic hypertrophic subaortic stenosis (IHSS) with significant coronary atherosclerosis is little known, only 43 cases being available in the literature, 2 of which are personal ones. But the incidence of this association has certainly been underestimated. It is especially found from the sixth decade onwards, and at least 20% of patients with IHSS in and above the age group have stenosing lesions of the coronary artery. It is almost impossible to establish the presence of associated coronary abnormalities from the clinical features of from electrocardiogram. It does however seem worthwhile looking for this condition in IHSS when there is refractory chest pain, especially to beta-blockers, particularly if the patient is aged over 50 and has risk factors for ischaemic heart disease. It is also good to find IHSS associated with known coronary artery disease by using simple non-invasive techniques such as phonomechanocardiography and especially echo-cardiography; it is important not to miss the myocardial lesion and to treat concurrently if there is likely to be an indication for dealing with the coronary arteries surgically. The beta-blockers are the treatment of choice for both conditions, together with anticoagulents. If they fail, myectomy or myotomy together with aorto-coronary bypass graft should be considered.
特发性肥厚性主动脉瓣下狭窄(IHSS)与严重冠状动脉粥样硬化的关联鲜为人知,文献中仅有43例相关报道,其中2例为本人经手病例。但这种关联的发生率肯定被低估了。这种情况尤其在60岁以后出现,在该年龄及以上的IHSS患者中,至少20%存在冠状动脉狭窄病变。从临床特征或心电图几乎无法确定是否存在相关的冠状动脉异常。然而,当IHSS患者出现难治性胸痛,尤其是对β受体阻滞剂难治时,特别是患者年龄超过50岁且有缺血性心脏病危险因素时,筛查这种情况似乎是值得的。通过使用简单的非侵入性技术,如心音图,尤其是超声心动图,发现IHSS与已知冠状动脉疾病相关也很好;重要的是不要漏诊心肌病变,如果可能有手术治疗冠状动脉的指征,则应同时进行治疗。β受体阻滞剂是这两种疾病的首选治疗药物,同时可使用抗凝剂。如果治疗失败,应考虑进行心肌切除术或心肌切开术以及主动脉冠状动脉搭桥术。