通过天然异硫氰酸葡萄糖芥苷的化学选择性氧化形成萝卜硫苷：一种合成萝卜硫素的化学酶法途径。
Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: a chemoenzymatic route to sulforaphane.
作者信息
Iori R, Bernardi R, Gueyrard D, Rollin P, Palmieri S
机构信息
Istituto Sperimentale per le Colture Industriali, MiPA, Bologna, Italy.
出版信息
Bioorg Med Chem Lett. 1999 Apr 5;9(7):1047-8. doi: 10.1016/s0960-894x(99)00136-5.
Abstract
A new semi-synthetic way to produce glucoraphanin (2), the bio-precursor of the potential anticarcinogen sulforaphane (3), has been developed. Starting from glucoerucin (1), isolated from ripe seeds of Eruca sativa, glucoraphanin was obtained through chemoselective oxidation. Controlled myrosinase-catalysed hydrolysis of this precursor quantitatively afforded sulforaphane.
摘要
一种生产萝卜硫素（2）的新半合成方法已被开发出来，萝卜硫素是潜在抗癌剂萝卜硫烷（3）的生物前体。从从芝麻菜成熟种子中分离得到的异硫氰酸葡萄糖酯（1）开始，通过化学选择性氧化获得了萝卜硫素。该前体在黑芥子酶催化下的可控水解定量地生成了萝卜硫烷。
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