Kokotos G, Constantinou-Kokotou V, Noula C, Hadjipavlou-Litina D
Department of Chemistry, University of Athens, Panepistimiopolis, Greece.
Lipids. 1999 Mar;34(3):307-11. doi: 10.1007/s11745-999-0368-6.
Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic alpha-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.
本文描述了合成脂质氨基酸醇和二胺的简单有效方法。脂质2-氨基醇和1,3-二胺可以从合成脂质α-氨基酸开始合成。另外，市售的脂质1,2-二醇可用作合成2-氨基醇的起始原料。对合成的化合物进行的体内抗炎活性初步实验取得了有希望的结果。
