果蝇的dCREB2基因影响生物钟。
The Drosophila dCREB2 gene affects the circadian clock.
作者信息
Belvin M P, Zhou H, Yin J C
机构信息
Cold Spring Harbor Laboratory, New York 11724, USA.
出版信息
Neuron. 1999 Apr;22(4):777-87. doi: 10.1016/s0896-6273(00)80736-9.
Abstract
We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness. A mutation in dCREB2 shortens circadian locomotor rhythm in flies and dampens the oscillation of period, a known clock gene. Cycling dCREB2 activity is abolished in a period mutant, indicating that dCREB2 and Period affect each other and suggesting that the two genes participate in the same regulatory feedback loop. We propose that dCREB2 supports cycling of the Period/Timeless oscillator. These findings support CREB's role in mediating adaptive behavioral responses to a variey of environmental stimuli (stress, growth factors, drug addiction, circadian rhythms, and memory formation) in mammals and long-term memory formation and circadian rhythms in Drosophila.
摘要
我们报告了果蝇中CREB/CREM的同源物dCREB2在昼夜节律中的作用。在果蝇中，无论是在明暗周期还是在持续黑暗中，dCREB2的活性都以24小时的节律循环。dCREB2的一个突变缩短了果蝇的昼夜运动节律，并减弱了已知生物钟基因周期（period）的振荡。在一个周期突变体中，循环的dCREB2活性被消除，这表明dCREB2和周期基因相互影响，并提示这两个基因参与同一个调节反馈回路。我们提出，dCREB2支持周期基因/无时间基因（Period/Timeless）振荡器的循环。这些发现支持了CREB在介导哺乳动物对各种环境刺激（应激、生长因子、药物成瘾、昼夜节律和记忆形成）的适应性行为反应以及果蝇的长期记忆形成和昼夜节律中的作用。
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