Roushdi I M, Ibrahim E S, Habib N S
Pharmazie. 1976;31(12):856-9.
The isolation of phthiocol (3-hydroxy-2-methyl-1.4-naphthoquinone) from the acetone-soluble fat fraction of tubercle bacilli [1, 2] and the confirmation that it had antituberculous activity against H-37 R.V. strain [20] in vitro and in mice [12], prompted the synthesis of some 2-alkyl-3-hydroxy-1.4-naphthoquinone-4-aryl(aroyl)hydrazones as possible tuberculostatic agents.
从结核杆菌的丙酮可溶脂肪部分中分离出结核菌素（3-羟基-2-甲基-1,4-萘醌）[1,2]，并且证实其在体外对H-37 R.V.菌株[20]以及在小鼠体内[12]具有抗结核活性，这促使人们合成一些2-烷基-3-羟基-1,4-萘醌-4-芳基（芳酰基）腙作为可能的抗结核药物。
