Dal Pozzo A, Acquasaliente M, Donzelli G, Delor F, Ferruti P
Farmaco Sci. 1986 Aug;41(8):622-9.
Eight new aroyl-acrylic esters of polyethylene glycols were prepared using different synthetic ways. They are supposed to possess a higher activity as antimicotic agents for topical use, by favouring skin absorption. Except in few cases, the antimicrobial activity of the oligomeric derivatives resulted generally decreased in vitro, in comparison to simple alkyl esters previously prepared. However, only pharmacological screenings for antimicotic activity in vivo will give a definite response on whether the new derivatives are advantageous for topical use.
通过不同的合成方法制备了八种新型聚乙二醇芳酰丙烯酸酯。它们被认为作为局部用抗真菌剂具有更高的活性，因为有利于皮肤吸收。除少数情况外，与先前制备的简单烷基酯相比，低聚物衍生物的抗菌活性在体外普遍降低。然而，只有对体内抗真菌活性进行药理学筛选才能明确这些新衍生物是否有利于局部使用。
