Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols.

Eight new aroyl-acrylic esters of polyethylene glycols were prepared using different synthetic ways. They are supposed to possess a higher activity as antimicotic agents for topical use, by favouring skin absorption. Except in few cases, the antimicrobial activity of the oligomeric derivatives resulted generally decreased in vitro, in comparison to simple alkyl esters previously prepared. However, only pharmacological screenings for antimicotic activity in vivo will give a definite response on whether the new derivatives are advantageous for topical use.