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抗菌和抗真菌剂的研究。III. 2-甲基-5-芳基-3-呋喃甲酸和2-甲基-3-咪唑基甲基-5-芳基呋喃的合成及抗菌活性

Research on antibacterial and antifungal agents. III. Synthesis and antimicrobial activity of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolylmethyl-5-aryl furans.

作者信息

Porretta G C, Scalzo M, Chimenti F, Bolasco A, Biava M, Fischetti M, Riccardi F

机构信息

Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Universit La Sapienza, Roma, Italy.

出版信息

Farmaco Sci. 1987 Sep;42(9):629-39.

PMID:3691788
Abstract

The synthesis and microbiological activities of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolyl-methyl-5-aryl-3-furans are reported. Antimicrobial data in comparison with pyrrolnitrin showed an interesting antifungal activity but a very poor antibacterial activity. The presence of an imidazole nucleus does not increase antifungal activity. The introduction of a substituent in the para position of the aryl at a C5 of the furan ring affects antifungal activity.

摘要

报道了2-甲基-5-芳基-3-呋喃甲酸和2-甲基-3-咪唑基甲基-5-芳基-3-呋喃的合成及微生物活性。与硝吡咯菌素相比的抗菌数据显示出有趣的抗真菌活性，但抗菌活性非常差。咪唑核的存在并不会增加抗真菌活性。在呋喃环C5位的芳基对位引入取代基会影响抗真菌活性。

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