Cebollero-Santamaria F, Smith J, Gioe S, Van Frank T, Mc Call R, Airhart J, Perrillo R
Section of Gastroenterology and Hepatology, Alton Ochsner Medical Institutions, New Orleans, Louisiana, USA.
Am J Gastroenterol. 1999 May;94(5):1242-7. doi: 10.1111/j.1572-0241.1999.01073.x.
We sought to determine whether elderly patients with upper gastrointestinal bleeding can be safely managed as outpatients. We were also interested in determining the etiology of bleeding peptic ulcer disease in this population.
Eighty-four patients (65 yr of age and older) were studied during a 23-month period. Urgent outpatient endoscopy was performed and clinical as well as endoscopic criteria were applied to determine the need for hospital admission. Patients with endoscopic findings that indicated a low risk for rebleeding were not admitted if they lacked one major or three minor predefined clinical criteria. All enrollees were followed after discharge from the clinic or hospital for 4 wk with hematocrit determination and clinical assessments. The main outcome measures were the number of patients who met our predefined clinical and endoscopic criteria for outpatient versus inpatient care and the differences in the rebleeding rates in these two groups.
Twenty-four (29%) patients were treated as outpatients; none rebled. In contrast, seven (12%) of the 60 inpatients had one or more rebleeding episodes (p = 0.002). Bleeding from peptic ulcer disease was associated with use of nonsteroidal antiinflammatory medications in 81% of patients.
Selective outpatient management of elderly patients with upper gastrointestinal bleeding can be done safely and has the potential to lead to reduced health care expenditures. Over-the-counter nonsteroidal antiinflammatory drugs are the most frequent cause of bleeding peptic ulcer disease in this population.
我们试图确定老年上消化道出血患者是否可作为门诊患者安全管理。我们还对确定该人群中出血性消化性溃疡疾病的病因感兴趣。
在23个月期间对84例年龄在65岁及以上的患者进行了研究。进行了紧急门诊内镜检查,并应用临床及内镜标准来确定是否需要住院治疗。内镜检查结果显示再出血风险低的患者,如果缺乏一项主要或三项次要的预先定义的临床标准,则不收入院。所有登记患者在从诊所或医院出院后随访4周,测定血细胞比容并进行临床评估。主要结局指标是符合我们预先定义的门诊与住院治疗临床及内镜标准的患者人数,以及这两组患者再出血率的差异。
24例(29%)患者作为门诊患者治疗;无一例再出血。相比之下,60例住院患者中有7例(12%)发生了一次或多次再出血事件(p = 0.002)。81%的患者消化性溃疡疾病出血与使用非甾体抗炎药有关。
对老年上消化道出血患者进行选择性门诊管理是安全可行的,并且有可能降低医疗保健费用。非处方非甾体抗炎药是该人群中出血性消化性溃疡疾病最常见的病因。