Mrá P, Kapeller K
Z Mikrosk Anat Forsch. 1976;90(2):352-9.
The effects of colchicine and lumicolchicine on the ultrastructure of non-myelinated axons in cat autonomic nerves were studied using in vitro preparations of inferior mesenteric ganglion/hypogastric nerves. After 24 hrs of in vitro incubation with colchicine added to the medium (10 microng/ml) a significant decrease in number of neurotubules per 1 axon was observed. In the presence of a solution of alpha-beta and gamma-lumicolchicine (10 microng/ml) severe degenerative changes occured in axons and Schwann cells. At a lower dose of lumicolchicine (3 microng/ml) these changes were less frequent and the number of neurotubules per 1 axon did not differ from that in control nerves.
利用肠系膜下神经节/腹下神经的体外制备物，研究了秋水仙碱和光秋水仙碱对猫自主神经中无髓鞘轴突超微结构的影响。在培养基中添加秋水仙碱（10微克/毫升）进行24小时体外孵育后，观察到每1个轴突的神经微管数量显著减少。在存在α-β和γ-光秋水仙碱溶液（10微克/毫升）的情况下，轴突和施万细胞发生了严重的退行性变化。在较低剂量的光秋水仙碱（3微克/毫升）下，这些变化较少见，每1个轴突的神经微管数量与对照神经无差异。
