Baĭramkulov Kh D, Gatsura V V
Biull Eksp Biol Med. 1978 Sep;86(9):317-9.
The influence of d-ketoglutarate and succinate in acute experiments on dogs was studied by the following parameters: collateral coronary circulation (CCC) of the ischemic myocardium, systemic arterial pressure, and the content of lactic, pyruvic acids, and glucose in the blood flowing from the ischemic zone. alpha-ketoglutarate (6 mg/kg intracoronary and 60 mg/kg intravenously) proved to produce a positive effect on CCC and the contractile activity of the myocardium. Intravenous injection of alpha-ketoglutarate (12 mg/kg) and succinate (100 mg/kg) decreased significantly the consumption of glucose by the ischemic myocardium which rose after the ligation. In comparison with alpha-ketoglutarate, all doses of succinate were more effective as a factor of preventing the increase of lactic acid in the blood flowing from the ischemic zone. Thus, definite doses of alpha-ketoglutarate and succinate could be used for pharmacological correction of CCC and energy supply of the ischemic myocardium.
通过以下参数研究了α-酮戊二酸和琥珀酸在对狗进行的急性实验中的影响：缺血心肌的侧支循环（CCC）、体动脉血压以及从缺血区流出的血液中乳酸、丙酮酸和葡萄糖的含量。α-酮戊二酸（冠状动脉内注射6mg/kg，静脉注射60mg/kg）被证明对CCC和心肌的收缩活动产生积极影响。静脉注射α-酮戊二酸（12mg/kg）和琥珀酸（100mg/kg）可显著降低缺血心肌的葡萄糖消耗，而在结扎后葡萄糖消耗增加。与α-酮戊二酸相比，所有剂量的琥珀酸作为防止从缺血区流出的血液中乳酸增加的因素更有效。因此，特定剂量的α-酮戊二酸和琥珀酸可用于对CCC进行药理学纠正以及为缺血心肌提供能量。
