Prianishnikova N T, Samvelian V M, Diadiura Zh A
Biull Eksp Biol Med. 1976 Dec;82(12):1451-3.
The surface activity of the antiaarhythmic drugs and their influence on the lipid-containing interphasics were studied. It was found that drug No. 7351 (diphenyl isopropyl acetic acid diethyl aminopropyl ester), fubromegan, metamysil, propranolol, quinidine, novocalinamide, xylocaine, and trimecaine possessed surface activity. There exists a symbate relationship between the surface and especially the interphasic activity and the antiarrhythmic effect. The most active antiarrhythmic drug No. 7351 increased the electric conductivity of the lecithine bilayer membrane much more than novocainamide.
对抗心律失常药物的表面活性及其对含脂质界面的影响进行了研究。发现7351号药物（二苯基异丙基乙酸二乙氨基丙酯）、溴苄胺、美西律、普萘洛尔、奎尼丁、诺伏卡酰胺、利多卡因和三甲卡因具有表面活性。表面活性尤其是界面活性与抗心律失常作用之间存在协同关系。最具活性的抗心律失常药物7351号比诺伏卡酰胺更能增加卵磷脂双层膜的电导率。
