Franchimont P, Kicovic P M, Mattei A, Roulier R
Clin Endocrinol (Oxf). 1978 Oct;9(4):313-20. doi: 10.1111/j.1365-2265.1978.tb02216.x.
Effects on plasma T, DHT, A, FSH, LH and PRL concentrations and the pituitary responsiveness to the LHRH/TRH stimulation, as well as on libido and sexual, mental and physical activities were studied in ten hypogonadal male patients undergoing therapy with oral testosterone undecanoate (TU) for 9 weeks. The daily dose of TU needed for satisfactory clinical effect was 120 mg (6 cases) and 240 mg (4 cases). There was a significant rise in circulation androgen concentrations in all patients. Mean plasma T, DHT and A increased at 9 weeks from 1.20, 0.12 and 0.36 ng/ml to 4.34 (P less than 0.0004), 0.39 (P less than 0.0004) and 1.24 ng/ml (P less than 0.005), respectively. In hypergonadotrophic patients (N = 6) plasma FSH and LH fell progressively (P less than 0.05), while in hypogonadotrophic patients (N = 4) a marked rise in plasma FSH (P less than 0.05) was found, while LH tended to rise as well. Base-line plasma PRL remained unchanged. In three out of four patients with poor PRL response to TRH, normal responses were established after TU therapy. Increase in libido and sexual activity was reported by nine patients. An increase in mental and physical activity was found in seven and two patients, respectively. Tolerance was excellent. It was concluded that oral TU is an effective form of substitution therapy in male hypogonadal patients.
对10名性腺功能减退男性患者进行了研究，这些患者接受了9周的口服十一酸睾酮（TU）治疗，观察其对血浆睾酮（T）、双氢睾酮（DHT）、雄烯二酮（A）、促卵泡生成素（FSH）、促黄体生成素（LH）和催乳素（PRL）浓度的影响，以及垂体对促黄体生成素释放激素（LHRH）/促甲状腺激素释放激素（TRH）刺激的反应，同时观察对性欲以及性、精神和身体活动的影响。达到满意临床效果所需的TU每日剂量为120毫克（6例）和240毫克（4例）。所有患者循环雄激素浓度均显著升高。9周时，血浆T、DHT和A的平均值分别从1.20、0.12和0.36纳克/毫升增至4.34（P<0.0004）、0.39（P<0.0004）和1.24纳克/毫升（P<0.005）。在促性腺激素分泌过多的患者（n = 6）中，血浆FSH和LH逐渐下降（P<0.05），而在促性腺激素分泌不足的患者（n = 4）中，血浆FSH显著升高（P<0.05），LH也有升高趋势。基线血浆PRL保持不变。在4例对TRH反应不良的患者中，有3例在TU治疗后恢复正常反应。9例患者报告性欲和性活动增加。分别有7例和2例患者发现精神和身体活动增加。耐受性良好。结论是口服TU是男性性腺功能减退患者替代治疗的有效形式。
