Weil J, Bidlingmaier F, Butenandt O, Sippell W G, Baumgartner W, Knorr D
Acta Endocrinol (Copenh). 1980 Oct;95(2):244-50. doi: 10.1530/acta.0.0950244.
The pharmacodynamics of plasma testosterone (T) and androstenedione (A) levels were studied in ten hypogonadal boys after oral administration of testosterone undecanoate (TU). Plasma T and A levels were measured by specific radioimmunoassays. Six hours after a single dose of 120 mg TU, there was a significant increase (P < 0.005) in plasma T and A with a median T peak level of 940 ng/100 ml. Furthermore, twelve agonadal boys treated with a mean dose of 60 mg TU/day were examined over a period of 18-24 months. During this therapy, plasma T and A levels were significantly higher than before (P < 0.005), whereas plasma levels of LH and FSH did not decrease significantly. With the exception of one anorchic boy, all patients showed signs of sexual maturation, such as growth of pubic and axillary hair, and steady development of bone age during oral TU treatment.
对10名性腺功能减退男孩口服十一酸睾酮（TU）后血浆睾酮（T）和雄烯二酮（A）水平的药效学进行了研究。血浆T和A水平通过特定放射免疫测定法进行测量。单次服用120mg TU 6小时后，血浆T和A显著升高（P<0.005），T峰值水平中位数为940ng/100ml。此外，对12名平均剂量为60mg TU/天的性腺功能减退男孩进行了18 - 24个月的检查。在该治疗期间，血浆T和A水平显著高于治疗前（P<0.005），而血浆促黄体生成素（LH）和促卵泡生成素（FSH）水平没有显著下降。除1名无睾男孩外，所有患者在口服TU治疗期间均表现出性成熟迹象，如阴毛和腋毛生长以及骨龄稳步发育。
