Kuzel M, Zinneman H, Nelson W, Halberg F, Rosen G, Scheving L E, Haus E
Chronobiologia. 1978 Jul-Sep;5(3):295-311.
Eighty-four singly housed LOU rats, 43 males and 41 females, were studied (under conditions standardized for rhythmometry) for the effect of methylprednisolone sodium succinate (MP) upon a transplantable immunocytoma. Body temperature was monitored as a host reference rhythm while light chain excretion and tumor size were monitored to determine an effect upon the tumor. The MP, dissolved in a sweet solution, was consumed by the rats without any statistically significant shift in acrophase of the circadian temperature rhythm. Time dependent effects of MP treatment were observed with respect to 1) tumor size decrement and 2) the survival of treated animals, as compared to untreated animals.
对84只单独饲养的LOU大鼠（43只雄性和41只雌性）进行了研究（在节律测量标准化的条件下），以观察琥珀酸钠甲泼尼龙（MP）对可移植免疫细胞瘤的影响。监测体温作为宿主参考节律，同时监测轻链排泄和肿瘤大小以确定对肿瘤的影响。溶解在甜味溶液中的MP被大鼠摄入，昼夜体温节律的峰相位没有任何统计学上的显著变化。与未治疗的动物相比，观察到MP治疗在时间上对1）肿瘤大小减小和2）治疗动物的存活有影响。
