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[辐射损伤条件下的ATP代谢及其调节方式]

[ATP metabolism under conditions of radiation injury and the ways of its modification].

作者信息

Miroshnichenko Z N, Kucherenko N E, Tsudzevich B A

出版信息

Vopr Med Khim. 1976 May-Jun;22(3):311-8.

PMID:1025893
Abstract

Content, methylation and an intensity of restoration of phosphoric components of ATP were studied in cross-striated muscles, brain and liver tissue of normal animals. These patterns were also studied in animals, subjected to irradiation: within 3 hrs after X-ray treatment (800 r); with subcutaneous administration of prozerine (0.5 mcg/kg) and nicotinic acid (20 microng/) 4 hrs before decapitation; and also in animals with vagus, cut off at the level of neck two weeks before irradiation. In different experimental conditions the character of regularity and interrelation between methylation and phosphorylation of ATP were established.

摘要

对正常动物的横纹肌、脑和肝组织中ATP磷酸成分的含量、甲基化及恢复强度进行了研究。还对接受照射的动物进行了这些指标的研究:X射线治疗(800伦琴)后3小时内;断头前4小时皮下注射毒扁豆碱(0.5微克/千克)和烟酸(20微克/);以及在照射前两周在颈部水平切断迷走神经的动物。在不同实验条件下,确定了ATP甲基化和磷酸化之间规律的特征及相互关系。

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