Anger J P, Anger F, Cano Y, Chauvel Y, Louvet M, Van den Driessche J
Eur J Toxicol Environ Hyg. 1976 Nov-Dec;9(6):339-46.
The authors report a toxicological study of bis (tributyltin oxide) (TBTO) given by inhalation (oily aerosol) to 105 Hartley albino guinea pigs. Doses vary from 1 mg to 0.1 mg of TBTO per liter of aerosol. Death occurs for doses of 0.2 mg per le more resistant than the male ones. The intoxication is marked by a period of ocular and nasal irritation followed by a short remission time, then death occurs after asphyxic convulsions. With doses less than 0.2 mg per liter of aerosol, we observe only an irritation without mortality after one hour intoxication. Seven days later the animals are alive. Because of its liposulibility, TBTO is present in the whole body, particularly in liver, kidney, lung, brain and heart. Histological study does not reveal any peculiar lesion of the examinated organs. Especially there is no specific alteration of the respiratory system. The merely observed trouble is a diffuse congestion.
作者报告了一项对105只哈特利白化豚鼠进行吸入（油性气雾剂）双（三丁基氧化锡）（TBTO）的毒理学研究。气雾剂中TBTO的剂量从每升1毫克到0.1毫克不等。每升0.2毫克以上的剂量会导致死亡，雌性比雄性更具抵抗力。中毒表现为一段时间的眼部和鼻部刺激，随后缓解时间较短，然后在窒息性惊厥后死亡。当气雾剂剂量低于每升0.2毫克时，中毒一小时后我们仅观察到刺激而无死亡。七天后动物仍然存活。由于其脂溶性，TBTO存在于全身，特别是在肝脏、肾脏、肺、脑和心脏中。组织学研究未发现所检查器官有任何特殊病变。特别是呼吸系统没有特异性改变。仅观察到的问题是弥漫性充血。
