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氧化三丁基锡油性气雾剂对小鼠探究行为的影响(作者译)

[Influence of a tributyltin oxide oily aerosol on the exploratory behaviour toward the mouse (author's transl)].

作者信息

Truhaut R, Anger J P, Reymann J M, Chauvel Y, Van den Driessche J

出版信息

Toxicol Eur Res. 1979 Jul;2(4):181-6.

PMID:547450
Abstract

Inhalation of an oily aerosol of bis (tributyltin oxide) (TBTO) after single or repeated expositions (1 hour) disturb the exploratory behaviour in the mouse. Weak concentrations (42 and 84 ppm) stimulate exploratory activity while large doses (170 and 340 ppm) significantly decrease it. Modification in brain amine levels may appear but the observed perturbance seems to be more dependent from oily vehicule than TBTO itself.

摘要

单次或重复暴露(1小时)后吸入双(三丁基氧化锡)(TBTO)的油性气雾剂会干扰小鼠的探究行为。低浓度(42和84 ppm)会刺激探究活动,而高剂量(170和340 ppm)则会显著降低探究活动。可能会出现脑胺水平的改变,但观察到的干扰似乎更多地取决于油性载体而非TBTO本身。

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Toxicol Eur Res. 1979 Jul;2(4):181-6.
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