Korpachev V V, Gordienko V M, Oleĭnik B V
Farmakol Toksikol. 1976 May-Jun;39(3):319-24.
Over a periof of 12 days following introduction of o'p-dichlordiphenyl-chlorethane to dogs in a dose of 25 mg/kg a sizable accumulation of the compound in the adrenal tissue, a drastic inhibition of its function and deragment of the suprarenal cortex structure are observed. After a 28-day administration of the compound the functional and structural upsets in the adrenals gain in strength, whereas it concentration in this organ declines.
给狗按25毫克/千克的剂量引入双对氯苯基三氯乙烷后12天内,观察到该化合物在肾上腺组织中有相当大的蓄积,其功能受到强烈抑制,肾上腺皮质结构遭到破坏。给予该化合物28天后,肾上腺的功能和结构紊乱加剧,而该器官中其浓度下降。