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[O,N'-二氯二苯二氯乙烷和培坦对犬和豚鼠肾上腺中谷胱甘肽还原酶活性的体外作用]

[Effect of O,N'=dichlorodiphenyldichloroethane and pertan in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs].

作者信息

Komissarenko V P, Chelnakova I S, Mikosha A S

出版信息

Biull Eksp Biol Med. 1978 Feb;85(2):159-61.

PMID:630087
Abstract

Glutathione reductase is activated by o,p'-dichlorodiphenyldichlorethane (o,p'-DDD) and pertan added in a concentration of 312 micrometer to the homogenate and cytoplasmic fraction of the dog adrenals. At a concentration of 156 micrometer o,p'-DDD and pertan failed to influence the glutathione reductase activity of the dog adrenal glands. Added in vitro, o,p'-DDD and pertan activate glutatione reductase of the quinea pig adrenal glands. O,p'-DDD does not affect the glutathione reductase activity of the liver and kidney cytoplasmic fraction in dogs. This observation confirms the high specificity of o,p'-DDD action on the adrenal glands.

摘要

谷胱甘肽还原酶可被添加到犬肾上腺匀浆和细胞质部分、浓度为312微摩尔的邻，对'-二氯二苯二氯乙烷（邻，对'-滴滴滴）和培丹激活。当邻，对'-滴滴滴和培丹浓度为156微摩尔时，未能影响犬肾上腺的谷胱甘肽还原酶活性。在体外添加时，邻，对'-滴滴滴和培丹可激活豚鼠肾上腺的谷胱甘肽还原酶。邻，对'-滴滴滴不影响犬肝脏和肾脏细胞质部分的谷胱甘肽还原酶活性。这一观察结果证实了邻，对'-滴滴滴对肾上腺作用的高度特异性。

相似文献

1
[Effect of O,N'=dichlorodiphenyldichloroethane and pertan in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs].[O,N'-二氯二苯二氯乙烷和培坦对犬和豚鼠肾上腺中谷胱甘肽还原酶活性的体外作用]
Biull Eksp Biol Med. 1978 Feb;85(2):159-61.
2
[The effect of o,p'-dichlorodiphenyldichloroethane on malic enzyme activity of the adrenal glands].[邻对二氯二苯二氯乙烷对肾上腺苹果酸酶活性的影响]
Vopr Med Khim. 1985 Jan-Feb;31(1):61-4.
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[Activity of glutathione reductase in the adrenal glands and the liver of dogs after administration O,P-DDD, perthane and ACTH].[给予O,P-DDD、过氯乙烯和促肾上腺皮质激素后犬肾上腺和肝脏中谷胱甘肽还原酶的活性]
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):95-8.
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[Effect of chloditan on the changes of activity of glutathione transferase, glutathione reductase and glutathione content in the adrenal glands and liver in rats].[氯地孕酮对大鼠肾上腺和肝脏中谷胱甘肽转移酶、谷胱甘肽还原酶活性及谷胱甘肽含量变化的影响]
Fiziol Zh (1994). 1994 Jan-Feb;40(1):86-90.
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Effect of o,p'-dichlorodiphenyldichloroethane on glutathione reductase activity and content of SH groups in the dog adrenals.邻对二氯二苯二氯乙烷对犬肾上腺中谷胱甘肽还原酶活性及巯基含量的影响。
Bull Exp Biol Med. 1975 Jan;77(7):761-3. doi: 10.1007/BF00799312.
6
[Insensitivity of purified glutathione reductase from adrenal cortex to o,p'-dichlorodiphenyldichloroethane].[肾上腺皮质纯化谷胱甘肽还原酶对o,p'-二氯二苯二氯乙烷不敏感]
Ukr Biokhim Zh (1978). 1982 Jul-Aug;54(4):400-4.
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[Chloditan-induced changes in lipid peroxidation in the adrenals of dogs and guinea pigs].[氯地孕酮对犬和豚鼠肾上腺脂质过氧化的影响]
Biull Eksp Biol Med. 1989 Feb;107(2):171-4.
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[Effect of o,p'-dichlorodiphenyldichloroethane on glutathione reductase activity and on the SH-group content in the adrenals of dogs].[邻对二氯二苯二氯乙烷对犬肾上腺中谷胱甘肽还原酶活性及巯基含量的影响]
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[The effect of ascorbate, NADPH and chloditan on lipid peroxidation in the adrenal glands of dogs and guinea pigs in vitro].[抗坏血酸盐、还原型辅酶Ⅱ和氯地孕酮对犬和豚鼠肾上腺体外脂质过氧化的影响]
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[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].[线粒体和微粒体电子传递的变化受邻，对'-二氯二苯二氯乙烷的影响]
Ukr Biokhim Zh (1978). 1981 Nov-Dec;53(6):74-7.