Driscoll W S, Heifetz S B, Korts D C
J Am Dent Assoc. 1978 Nov;97(5):820-4. doi: 10.14219/jada.archive.1978.0402.
Two groups of children, initially in the first and second grades, chewed, rinsed with, and swallowed an acidulated phosphate-fluoride tablet containing 1 mg of fluoride either once or twice a day in school. A control group of children followed the procedure once a day using a placebo tablet. An evaluation after six years of treatments showed that both the once-a-day and the twice-a-day procedures with fluoride tablets effectively reduced the incidence of dental caries.
两组儿童，最初分别为一年级和二年级，在学校每天咀嚼、含漱并吞咽一片含1毫克氟化物的酸化磷酸氟片一次或两次。一组对照组儿童每天使用安慰剂片进行一次相同操作。经过六年治疗后的评估显示，每天服用一次和每天服用两次氟片的方法均有效降低了龋齿发病率。
