Shern R J, Driscoll W S, Korts D C
J Am Dent Assoc. 1977 Aug;95(2):310-4. doi: 10.14219/jada.archive.1977.0445.
This study measured the fluoride in tooth enamel of 338 schoolchildren after daily use of acidulated phosphate-fluoride (APF) tablets, and investigated the relationship between observed amounts of enamel fluoride and incidence of caries. Randomly selected study groups received under supervision either one placebo tablet, one APF tablet containing 1 mg fluoride, or 2 APF tablets (3 hours apart) each school day. An abrasive enamel-type biopsy of a maxillary central incisor was taken 30 months after the start of fluoride tablet treatments at the time of the follow-up examinations. Mean fluoride levels in the biopsied enamel from each of the three groups were similar despite a significant restriction in caries in the group receiving two APF tablets per day. These findings suggest that fluoride can restrict dental caries by some mechanism other than fluoride uptake in the enamel.
本研究测量了338名学童每日使用酸化磷酸氟（APF）片剂后牙釉质中的氟含量，并调查了观察到的牙釉质氟含量与龋齿发病率之间的关系。随机选择的研究组在监督下，每个上学日服用一片安慰剂片剂、一片含1毫克氟的APF片剂或两片APF片剂（间隔3小时）。在氟化物片剂治疗开始30个月后的随访检查时，对上颌中切牙进行了磨蚀性牙釉质活检。尽管每天服用两片APF片剂的组龋齿明显减少，但三组活检牙釉质中的平均氟含量相似。这些发现表明，氟可以通过牙釉质中氟摄取以外的某种机制限制龋齿。
