Hogerzeil L M
Lepr India. 1976 Oct;48(4 Suppl):718-21.
A study was undertaken in 14 patients and 20 controls to find out if Lamprene can prevent a flare-up of the infection with Myco. leprae in patients who are on long-term steroid therapy on account of persistent reaction or neuritis. All patients were lepromatus (LL). The average duration of treatment was 21 months for the patients on Lamprene combined with steroids and 22 months for the patients on Lamprene only. There was no significant difference between the two groups in the reduction of either the MI (morphological index) or BI (bacteriological index). It appears that long-term steroids therapy has no adverse effect on the bacteriological decline in lepromatous patients provided that they are treated with Lamprene at the same time.
对14名患者和20名对照者进行了一项研究，以确定氯法齐明能否预防因持续性反应或神经炎而接受长期类固醇治疗的麻风分枝杆菌感染患者感染复发。所有患者均为瘤型麻风（LL）。接受氯法齐明联合类固醇治疗的患者平均治疗时长为21个月，仅接受氯法齐明治疗的患者平均治疗时长为22个月。两组在降低形态学指数（MI）或细菌学指数（BI）方面无显著差异。看来，只要同时使用氯法齐明进行治疗，长期类固醇治疗对瘤型麻风患者的细菌学衰退没有不良影响。
