[Effect of hydrocortisone and insulin on the synthesis of ribonucleic acids in the nuclei and cytoplasm of the liver cells of sexually immature male rates].

A prolonged (within 4 days) administration of hydrocortisone or protamin-Zn-insulin into preadolescent male rats with body weight of 70-90 g caused a distinct increase in the synthesis of DNA-like RNA, precursor of ribosomal RNA in nuclei and ribosomal RNA in cytoplasma of liver tissue. Protamin-Zn-insulin, after simultaneous administration with hydrocortisone, suppressed the increase in the synthesis of liver RNA fractions studied. The data obtained suggest that DNA-like RNA, precursor of ribosomal RNA from nuclei and ribosomal RNA from cytoplasma of liver tissue of preadolescent male rats participate in the synthesis of transaminases in liver tissue. The signigicant role of androgenes was assumed to consist in carring out the inducing effect of glucocorticoids and insulin, which influenced to a variable degree the synthesis of DNA-like RNA, of ribosomal RNA precursors from nuclei and of ribosomal RNA from liver tissue cytoplasma in preadolescent and adult animals.