[Delay in thrombin clearance as a diagnostic test of prethrombosis in depression of the anticoagulation system caused by atherogenic diet].

Decrease in 131I-thrombin clearance and decrease in absorption of complexes of thrombin with other substances in liver tissue were observed under conditions of depression of anticoagulation system found in animals maintained on altherogenic diet. Prolonged administration of an antisclerotic drug "Linetol" and of vitamin A into these animals promoted restoration of anticoagulation system. The restoration was tested by intensification of 131I-thrombin clearance and by accumulation of 131I-thrombin-heparin complex in liver tissue. Decrease in thrombin clearance, in combination with other tests, could be used for diagnosis of prethrombosis under conditions of experimental depression of anti-coagulation system.