Ul'ianov A M, Liapina L A, Bazaz'ian G G, Boneva Zh S
Vopr Med Khim. 1981;27(4):458-62.
After intravenous infusion of the thromboplastin-35- S-heparin complex into rats, maintained on the atherogenic diet within a prolonged period, distribution of the label in the animal tissues and its clearance were studied; total and non-enzymatic fibrinolytic activities were estimated. Inhibition of functions of the anticoagulation system, caused by long-term atherogenic diet in the animals, led to inhibition of the initial steps of heparin clearance as well as to alteration of the glycosaminoglycan distribution in various tissues. At the same time, formation and accumulation of heparin complexes as well as the non-enzymatic fibrinolytic activity were decreased in some tissues.
给长期食用致动脉粥样化饮食的大鼠静脉输注凝血活酶 -35-S-肝素复合物后，研究了标记物在动物组织中的分布及其清除情况；并评估了总纤维蛋白溶解活性和非酶促纤维蛋白溶解活性。长期致动脉粥样化饮食导致动物体内抗凝系统功能受到抑制，这不仅抑制了肝素清除的初始步骤，还改变了糖胺聚糖在各种组织中的分布。与此同时，某些组织中肝素复合物的形成与积累以及非酶促纤维蛋白溶解活性均有所降低。
