De Cremoux H, Hornebeck W, Jaurand M C, Bignon J, Robert L
J Pathol. 1978 Aug;125(4):171-7. doi: 10.1002/path.1711250402.
An elastinolytic activity on soluble and insoluble elastin has been demonstrated in the culture medium of human and monkey alveolar macrophages. This activity is potentiated by latex particles in the medium. An enzyme resembling some other elastases was partially purified and characterised. It differs from other elastases in its affinity for elastin and a synthetic substrate, its susceptibility to various kinds of inhibitors and by its metal ion requirement.
在人和猴肺泡巨噬细胞的培养基中已证实存在对可溶性和不溶性弹性蛋白的弹性蛋白酶活性。培养基中的乳胶颗粒可增强这种活性。一种类似于其他一些弹性蛋白酶的酶被部分纯化并进行了表征。它在对弹性蛋白和合成底物的亲和力、对各种抑制剂的敏感性以及对金属离子的需求方面与其他弹性蛋白酶不同。
