Miwa L J, Randall R J
Hosp Formul. 1986 Nov;21(11):1140-3, 1146.
The feasibility of instituting an adverse drug reaction (ADR) monitoring program was examined. Nurses and pharmacists were requested to fill out an ADR report form whenever a change in a patient's condition or a medication order raised suspicion of a possible ADR. The reports were investigated by the clinical pharmacy resident and evaluated for probable causal relationship, severity, and mechanism. The process used for reporting ADRs is described, and the parameters used to define an ADR are defined. The success of this program in increasing the number of ADR reports is evaluated, and the amount of time required by the various monitors is estimated. This voluntary ADR reporting system did increase ADR documentation in the study institution and may be adopted by P & T Committees in other hospitals.
对建立药物不良反应（ADR）监测项目的可行性进行了研究。要求护士和药剂师在患者病情变化或医嘱引发可能的ADR怀疑时填写ADR报告表。临床药学住院医师对报告进行调查，并评估其可能的因果关系、严重程度和机制。描述了ADR报告所采用的流程，并定义了用于定义ADR的参数。评估了该项目在增加ADR报告数量方面的成效，并估算了各监测人员所需的时间。这种自愿性ADR报告系统确实增加了研究机构中ADR的记录，其他医院的药事与治疗委员会（P&T Committees）也可采用。
