Lo Cascio V, Cominacini L, Adami S, Galvanini G, Cinti S, Bianchi I, Scuro L A
Quad Sclavo Diagn. 1976 Dec;12(4):393-40.
Automated laboratory procedures have made possible to "screen" a large population for specific biochemical abnormalities. Primitive hyperparathyroidism is for several respects an excellent disease model for testing "mass screening". Il is often asymptomatic, not uncommon, and is manifested by abnormalities in the levels of serum calcium and inorganic phosphorus, that can be detected cheaply with automated equipment. A computer program has been developed to screen patients with hypercalcaemia. During a period of 18 months 22720 hospitalized patients were investigated by the evaluation of serum calcium, and 80 hypercalcaemic patients were found. The diagnosis of primary hyperparathyroidism was established in 24 patients (in 19 histologically confirmed) so that the incidence of primary hyperparathyroidism (1,05%) compares favorably with that reported from some foreign Authors.
自动化实验室程序已使对大量人群进行特定生化异常“筛查”成为可能。原发性甲状旁腺功能亢进在几个方面是用于测试“大规模筛查”的理想疾病模型。它通常无症状，并不罕见，且表现为血清钙和无机磷水平异常，而这些异常可以通过自动化设备廉价检测出来。已经开发了一个计算机程序来筛查高钙血症患者。在18个月的时间里，通过评估血清钙对22720名住院患者进行了调查，发现了80名高钙血症患者。24例患者被诊断为原发性甲状旁腺功能亢进（19例经组织学证实），因此原发性甲状旁腺功能亢进的发病率（1.05%）与一些国外作者报道的发病率相比很可观。
