Clouet P, Carlier H, Blond J P, Bezard J
Ann Nutr Aliment. 1976;30(4):537-48.
Mitochondria from heart of rats fed a diet rich in rapeseed oil for two months from weaning, oxidized oleic acid a little better than those from animals fed a control diet containing peanut oil; but their activity decreased much more in presence of potassium cyanide which is an oxidation inhibitor. When observed by electronic microscopy, mitochondria from heart of rats fed rapeseed oil were more mumerous and more mitochondria of great size were encountered as compared with control rats. Biochemical data seemed to show a decrease of activity or quantity of certain enzymatic systems in mitochondria from heart of animals fed rapseed oil. Cyanide could more easily inhibit these enzymatic systems because of their deficiency. It can be thought that it is the mitochondria of great size which are implicated in this phenomenon since their growth is not accompanied by an increase of their content in certain enzymes which are just sensitive to cyanide. A mixture richer in mitochondria of big size, thus poorer in certain enzymes for an equal protein content in drastic conditions, such as partial anoxia since cyanide blocks the respiratory chain.
从断奶起用富含菜籽油的饲料喂养两个月的大鼠心脏中的线粒体，氧化油酸的能力比用含花生油的对照饲料喂养的动物的线粒体略强；但在存在作为氧化抑制剂的氰化钾时，它们的活性下降得更多。用电镜观察时，与对照大鼠相比，用菜籽油喂养的大鼠心脏中的线粒体数量更多，且遇到的大型线粒体更多。生化数据似乎表明，用菜籽油喂养的动物心脏线粒体中某些酶系统的活性或数量有所下降。由于这些酶系统缺乏，氰化物更容易抑制它们。可以认为，正是大型线粒体参与了这一现象，因为它们的生长并没有伴随着对氰化物敏感的某些酶含量的增加。在诸如局部缺氧等极端条件下，由于氰化物阻断呼吸链，在蛋白质含量相同的情况下，大型线粒体含量更高、某些酶含量更低的混合物。
