Chinyanga H M, Fletcher J J, Vartanian G A
West Afr J Pharmacol Drug Res. 1976 Dec;3(2):90-101.
The increase in the amplitude of the E.C.G. and ventricular contractile force induced by chloroquine sulphate was studied in frogs. It was shown that changes originated in the midbrain and were mediated through the sympathetic nervous system. The transmitter was recognized as a beta-adrenergic agent. The possible mechanism of action of chloroquine on the CNS responsible for the phenomenon observed was discussed.
在青蛙身上研究了硫酸氯喹引起的心电图振幅增加和心室收缩力增强。结果表明,这些变化起源于中脑,并通过交感神经系统介导。递质被认为是一种β-肾上腺素能物质。讨论了氯喹对中枢神经系统产生所观察到现象的可能作用机制。