• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

氯喹引起青蛙心电图电压升高及心脏收缩力增强。

Increase of electrocardiogram voltage and contractile force of the frog's heart induced by chloroquine.

作者信息

Chinyanga H M, Fletcher J J, Vartanian G A

出版信息

West Afr J Pharmacol Drug Res. 1976 Dec;3(2):90-101.

PMID:1029912
Abstract

The increase in the amplitude of the E.C.G. and ventricular contractile force induced by chloroquine sulphate was studied in frogs. It was shown that changes originated in the midbrain and were mediated through the sympathetic nervous system. The transmitter was recognized as a beta-adrenergic agent. The possible mechanism of action of chloroquine on the CNS responsible for the phenomenon observed was discussed.

摘要

在青蛙身上研究了硫酸氯喹引起的心电图振幅增加和心室收缩力增强。结果表明,这些变化起源于中脑,并通过交感神经系统介导。递质被认为是一种β-肾上腺素能物质。讨论了氯喹对中枢神经系统产生所观察到现象的可能作用机制。

相似文献

1
Increase of electrocardiogram voltage and contractile force of the frog's heart induced by chloroquine.氯喹引起青蛙心电图电压升高及心脏收缩力增强。
West Afr J Pharmacol Drug Res. 1976 Dec;3(2):90-101.
2
The effects of dyphylline [7-(2,3-dihydroxypropyl) theophylline] on the toxicity of hycanthone on the frog's heart.二羟丙茶碱[7-(2,3-二羟丙基)茶碱]对海恩酮对蛙心毒性的影响。
Egypt J Bilharz. 1976;3(1):89-99.
3
[Action mechanism of angiotensin II on norepinephrine release].[血管紧张素II对去甲肾上腺素释放的作用机制]
Kokyu To Junkan. 1984 Nov;32(11):1131-4.
4
[The effect of chlorpromazine on the mechanogram, electrocardiogram and membranopotential of the frog heart].[氯丙嗪对蛙心机械图、心电图及膜电位的影响]
Acta Biol Med Ger. 1975;34(5):751-9.
5
Prolonged supramaximal stimulation of canine efferent sympathetic neurons induces desensitization of inotropic responses without a change in myocardial beta-adrenergic receptors.对犬传出交感神经元进行长时间的超最大刺激会诱导变力反应脱敏,而心肌β-肾上腺素能受体无变化。
Can J Cardiol. 1992 Mar;8(2):177-86.
6
[Organization of reflex sympathetic influence on rate and force of cardiac contraction].[反射性交感神经对心脏收缩速率和力量的影响机制]
Biull Eksp Biol Med. 1992 Jul;114(7):3-5.
7
Some observations on the effects of hycanthone on frog's heart and investigation of its site of action.关于海蒽酮对蛙心作用的一些观察及其作用部位的研究。
Egypt J Bilharz. 1975;2(2):277-84.
8
Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation.心脏钙电流的交感神经调节完全归因于环磷酸腺苷(cAMP)依赖性磷酸化。
Nature. 1991 Jun 13;351(6327):573-6. doi: 10.1038/351573a0.
9
Cardiovascular profile of mixidine fumarate, a compound which attenuates myocardial chronotropic responses.富马酸米昔丁的心血管特性,一种可减弱心肌变时反应的化合物。
J Pharmacol Exp Ther. 1980 Mar;212(3):514-8.
10
Noradrenaline release by nicotinic acid.烟酸引起的去甲肾上腺素释放
Indian J Physiol Pharmacol. 1975 Jul-Sep;19(3):129-34.

引用本文的文献

1
Cardiac effects and toxicity of chloroquine: a short update.氯喹的心脏效应和毒性:简短更新。
Int J Antimicrob Agents. 2020 Aug;56(2):106057. doi: 10.1016/j.ijantimicag.2020.106057. Epub 2020 Jun 19.