Murdoch L
Can J Hosp Pharm. 1982 May-Jun;35(3):79-85.
The solvent dimethyl sulfoxide (DMSO) has received intense lay publicity sporadically over the last two decades. The compound has been particularly promoted as an analgesic and anti-inflammatory agent. Its membrane penetrant-carrier properties have also been of prime interest. The history, physical/chemical and pharmacological properties, pharmacokinetics, clinical trials, therapeutic uses, side effects and dosage/administration of DMSO are reviewed. Legal implications and concerns with regard to DMSO use are presented in addition to advice for patients.
在过去二十年中，溶剂二甲基亚砜（DMSO）偶尔会受到公众的广泛关注。该化合物尤其被宣传为一种镇痛和抗炎剂。其膜渗透-载体特性也备受关注。本文综述了DMSO的历史、物理/化学和药理特性、药代动力学、临床试验、治疗用途、副作用以及剂量/给药方式。此外，还介绍了使用DMSO的法律影响和相关问题，并为患者提供了建议。
