Hanna C, Fraunfelder F T, Meyer S M
Ann Ophthalmol. 1977 Jan;9(1):61-5.
The anti-inflammatory properties of topical ocular dimethyl sulfoxide (DMSO) were investigated using a standard experimental model of an acute inflammatory ocular inflammation. Ninety percent and 100% DMSO aggravated the inflammatory response, 50% to 70% DMSO had similar responses as the control eye; however, 30% DMSO had definite anti-inflammatory properties. Dexamethasone 0.1% was superior to 30% DMSO as an anti-inflammatory agent. From this study it is evident that high concentrations of DMSO are irritating to the inflammatory ocular model used while lower concentrations have anti-inflammatory properties. The two side effects of skin irritation at the site of application and breath odor may be the subjective influence that leads certain patients to report a beneficial effect of DMSO treatment in ocular inflammation.
使用急性炎症性眼部炎症的标准实验模型，研究了局部眼部使用二甲基亚砜（DMSO）的抗炎特性。90%和100%的DMSO会加重炎症反应，50%至70%的DMSO与对照眼有相似的反应；然而，30%的DMSO具有明确的抗炎特性。0.1%的地塞米松作为抗炎剂优于30%的DMSO。从这项研究中可以明显看出，高浓度的DMSO对所使用的炎症性眼部模型有刺激性，而较低浓度具有抗炎特性。应用部位皮肤刺激和呼吸气味这两种副作用可能是导致某些患者报告DMSO治疗眼部炎症有有益效果的主观影响因素。
