Freeman G R
Laryngoscope. 1976 Jul;86(7):921-9. doi: 10.1288/00005537-197607000-00004.
The most controversial therapeutic agent in the past decade has been dimethylsulphoxide (DMSO), an industrial solvent to which great healing powers have been attributed. After initial laboratory testing, DMSO was rapidly introduced into veterinarian medicine and clinical medicine as an experimental agent with the ability to relieve pain, reduce swelling and edema in trauma, to show anesthetic, antibacterial and anti-inflammatory properties when applied topically to the skin. Ninety percent DMSO was used alone and in conjunction with alkaloids and antibiotics to test the clinical properties attributed to this drug. Although DMSO was found not to be ototoxic, laboratory and clinical testing which included double blind studies on patients with otological infections demonstrated that DMSO had no antibacterial, anesthetic or anti-inflammatory properties when applied within the external auditory canal. There was no indication that 90% DMSO, when combined with these various preparations, potentiated or acted synergistically to enhance their penetration through the dermal barrier.
在过去十年中，最具争议的治疗剂是二甲基亚砜（DMSO），一种被认为具有强大治愈能力的工业溶剂。经过初步实验室测试后，DMSO作为一种具有缓解疼痛、减轻创伤肿胀和水肿能力的实验剂，迅速被引入兽医学和临床医学，当局部应用于皮肤时，它还具有麻醉、抗菌和抗炎特性。90%的DMSO单独使用或与生物碱和抗生素联合使用，以测试赋予该药物的临床特性。尽管发现DMSO没有耳毒性，但包括对耳部感染患者进行双盲研究在内的实验室和临床测试表明，当在外耳道内使用时，DMSO没有抗菌、麻醉或抗炎特性。没有迹象表明90%的DMSO与这些不同制剂联合使用时，会增强或协同作用以促进它们穿透皮肤屏障。
