Powell H R
Dev Biol Stand. 1976 Oct;36:117-29.
The above discussion outlines some trends seen in the development of equipment for freeze-drying of various biological-like products. It has been pointed out that many similarities in equipment now exist. There are still areas in which a consensus on best design has not been reached and in these areas the user is offered some clear choices. Various changes have been introduced in recent years into freeze-drying equipment principally in an effort to increase reliability and improve the quality of the product produced. It is probable as more products are freeze-dried (and particularly as these products become more cost-sensitive) that manufacturers will also require that greater performance-capability be built into their equipment. This may perhaps translate into requirements for carrying high peak-vapor-rates and for automatic control in an effort to reduce drying cycles and increase throughput in a given machine.
上述讨论概述了各种类生物产品冷冻干燥设备发展过程中出现的一些趋势。已经指出,现在设备存在许多相似之处。仍有一些领域尚未就最佳设计达成共识,在这些领域为用户提供了一些明确的选择。近年来,冷冻干燥设备引入了各种变革,主要是为了提高可靠性并改善所生产产品的质量。随着越来越多的产品进行冷冻干燥(特别是随着这些产品对成本更加敏感),制造商可能还会要求其设备具备更高的性能。这可能转化为对承载高峰值蒸发速率以及自动控制的要求,以便减少干燥周期并提高给定机器的产量。