Millo R, Franzi A T, La Fauci M A
Riv Istochim Norm Patol. 1976;20(1-3):1-18.
The Authors have studied some aspects of the differentiation of gastric mucosa, during the prenatal and postnatal development in man and mouse. They have demonstrated that in both species the first elements of glandular rudiments can be already recognised, owing to the richness of their mitochondrial store, as parietal cells, where oxireductase activities are already present. The functional differentiation in the membrane of such elements takes place later on: from the point of view of the function the parietal cell can then be considered as completely differentiated. Chief cells, on the contrary, define their morphological and functional characters starting from the fifth month of foetal life. At any rate, at least for the studied characters, the gland store of human gastric mucosa, at birth and in the adult, is exactly alike.
作者研究了人类和小鼠产前及产后发育过程中胃黏膜分化的一些方面。他们证明，在这两个物种中，由于线粒体储存丰富，腺原基的最初成分可被识别为壁细胞，此时氧化还原酶活性已经存在。这些细胞的膜上的功能分化稍后发生：从功能角度看，壁细胞可被视为完全分化。相反，主细胞从胎儿期第五个月开始确定其形态和功能特征。无论如何，至少就所研究的特征而言，人类胃黏膜在出生时和成年时的腺体储备完全相同。
