Obreshkov K, Khadzhiev G
Vet Med Nauki. 1976;13(9):13-23.
Three local strains of lentogenic type of the Newcastle disease were used to produce live liquid vaccines. These were given per os to broiler chickens in order to test their immunogenicity (first vaccination at the age of 25 days and vaccination when 70 days old). The immunity thus acquired was followed serologically by the titer of the antihemagglutinins and the resistance manifested by the birds at the control infection with a proven lethal dose of a highly virulent velogenic strain of the Newcastle disease virus. The results obtained were compared with those observed with the use of liquid vaccines of the strains Hitchner-B1 and La Soto. It was concluded that the vaccines of the local Newcastle disease strains are completely harmless and immunogenic. The vaccinal strains are excreted by the immunized birds and serve to immunize the contact control chickens.
使用三种新城疫缓发型地方毒株生产活液疫苗。将这些疫苗经口给予肉鸡,以测试其免疫原性(25日龄首次接种,70日龄时再次接种)。通过抗血凝素滴度进行血清学跟踪所获得的免疫力,以及在以经证实的致死剂量的高致病性速发型新城疫病毒进行对照感染时鸡所表现出的抵抗力。将获得的结果与使用希钦纳 - B1株和拉索托株的液体制剂疫苗所观察到的结果进行比较。得出的结论是,地方新城疫毒株疫苗完全无害且具有免疫原性。接种疫苗的毒株会被免疫的鸡排出,并用于使接触的对照鸡免疫。