Kaz'min S D, Bagleĭ E A
Vopr Med Khim. 1976 Jan-Feb;22(1):26-30.
Hydrocortisone acetate caused the inhibition of the limphoma cells growing. In the process the aerobic glycolysis was increased, the respiratory activity was altered slightly but the magnitude of Crebtry effect was distinctly decreased. Under effect of the hormone the activity of pentose pathway was drastically increased: oxidation via 6-phosphogluconate and the synthesis of phosphorylated carbohydrates by "non-oxidative" pathway were increased 1.7- and 7.4-fold, respectively. Thus, the stopping of the tumor cells development occurred with simultaneous activation of the pentose-phosphate pathway and energy metabolism as a whole.
醋酸氢化可的松可抑制淋巴瘤细胞生长。在此过程中，有氧糖酵解增加，呼吸活性略有改变，但克雷布特里效应的幅度明显降低。在该激素的作用下，戊糖途径的活性大幅增加：通过6-磷酸葡萄糖酸的氧化以及“非氧化”途径的磷酸化碳水化合物合成分别增加了1.7倍和7.4倍。因此，肿瘤细胞发育的停止伴随着戊糖磷酸途径和整体能量代谢的同时激活。
