疟原虫的碳水化合物代谢
Carbohydrate metabolism of malarial parasites.
作者信息
Homewood C A
出版信息
Bull World Health Organ. 1977;55(2-3):229-35.
Abstract
The evidence for the pathways involved in the metabolism of carbohydrates by malarial parasites is critically reviewed. In all species studied, glucose is catabolized mainly by glycolysis with little participation of the pentose-phosphate pathway. It has not been proved conclusively that there is a functioning citric acid cycle in the intraerythrocytic stages of avian plasmodia, nor is it certain that these stages of any malarial parasites use oxygen.
摘要
对疟原虫碳水化合物代谢所涉及途径的证据进行了批判性综述。在所有研究的物种中，葡萄糖主要通过糖酵解进行分解代谢，戊糖磷酸途径参与较少。尚未确凿证明禽类疟原虫红细胞内阶段存在运转的柠檬酸循环，也不确定任何疟原虫的这些阶段是否利用氧气。
相似文献
1
Carbohydrate metabolism of malarial parasites.疟原虫的碳水化合物代谢
Bull World Health Organ. 1977;55(2-3):229-35.
2
Glucose metabolism in the simian malaria parasite Plasmodium knowlesi: activities of the glycolytic and pentose phosphate pathways during the intraerythrocytic cycle.
Ann Trop Med Parasitol. 1979 Oct;73(5):407-15. doi: 10.1080/00034983.1979.11687280.
3
Plasmodium falciparum carbohydrate metabolism: a connection between host cell and parasite.恶性疟原虫的碳水化合物代谢：宿主细胞与寄生虫之间的联系
Blood Cells. 1990;16(2-3):453-60; discussion 461-6.
4
5
Changes in the oxidative metabolism during maturation of amphibian oocytes.两栖类卵母细胞成熟过程中氧化代谢的变化。
J Embryol Exp Morphol. 1980 Oct;59:175-86.
6
The biochemistry of sugars.糖的生物化学
Int Z Vitam Ernahrungsforsch Beih. 1976;15:1-21.
7
Salvage syntheses and their relationship to nucleic acid metabolism.补救合成及其与核酸代谢的关系。
Bull World Health Organ. 1977;55(2-3):249-52.
8
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
J Lab Clin Med. 1969 Jul;74(1):1-11.
9
[Effect of hydrocortisone acetate on carbohydrate metabolism and cellular respiration of lymphoma NK/ly].
Vopr Med Khim. 1976 Jan-Feb;22(1):26-30.
10
Variations in structure and function during the life cycle of malarial parasites.疟原虫生命周期中结构和功能的变化。
Bull World Health Organ. 1977;55(2-3):139-56.
引用本文的文献
1
Low-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion.低剂量奎宁靶向KCNH6以增强葡萄糖诱导的胰岛素分泌。
J Mol Cell Biol. 2025 May 22;16(11). doi: 10.1093/jmcb/mjae051.
2
Fasting blood glucose in a Ghanaian adult is causally affected by malaria parasite load: a mechanistic case study using convergent cross mapping.加纳成年人的空腹血糖受疟原虫负荷的因果影响：使用会聚交叉映射的机制案例研究。
Malar J. 2022 Mar 18;21(1):93. doi: 10.1186/s12936-022-04076-y.
3
Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum.红细胞鞘氨醇激酶调节恶性疟原虫在红细胞内的发育。
Sci Rep. 2021 Jan 13;11(1):1257. doi: 10.1038/s41598-020-80658-7.
4
Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.大规模鉴定靶向疟原虫肝期的必需代谢过程。
Cell. 2019 Nov 14;179(5):1112-1128.e26. doi: 10.1016/j.cell.2019.10.030.
5
Exploring pancreatic pathology in Plasmodium falciparum malaria patients.探讨恶性疟原虫疟疾患者的胰腺病理学改变。
Sci Rep. 2018 Jul 11;8(1):10456. doi: 10.1038/s41598-018-28797-w.
6
Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.疟原虫分化以及适应不同宿主和媒介环境所需的阶段特异性代谢变化。
PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.
7
Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites.宿主网织红细胞提供了可被疟原虫利用的代谢储备库。
PLoS Pathog. 2015 Jun 4;11(6):e1004882. doi: 10.1371/journal.ppat.1004882. eCollection 2015 Jun.
8
Pharmacology of 8-aminoquinolines.8-氨基喹啉类药物的药理学
Bull World Health Organ. 1981;59(3):397-406.
9
Histochemical observations on the exoerythrocytic malaria parasite Plasmodium berghei in rat liver.
Histochemistry. 1984;81(5):417-25. doi: 10.1007/BF00489744.
10
Comparative biology of intracellular parasitism.细胞内寄生的比较生物学
Microbiol Rev. 1985 Sep;49(3):298-337. doi: 10.1128/mr.49.3.298-337.1985.
本文引用的文献
1
The metabolism of Plasmodium berghei, the malaria parasite of rodents. 2. An effect of mepacrine on the metabolism of glucose by the parasite separated from its host cell.伯氏疟原虫（啮齿动物的疟原虫）的代谢。2. 阿的平对从宿主细胞分离出的疟原虫葡萄糖代谢的影响。
Biochem J. 1961 Mar;78(3):472-8. doi: 10.1042/bj0780472.
2
[Maturation and aging processes in erythrocytes].[红细胞的成熟与衰老过程]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1961;78:364-81.
3
Glucose-6-phosphate and 6-phosphogluconate dehydrogenase activities in erythrocytes of monkeys infected with Plasmodium knowlesi.感染诺氏疟原虫的猴子红细胞中的葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶活性
Nature. 1962 Dec 29;196:1316-8. doi: 10.1038/1961316b0.
4
[Maturation processes in chick erythrocytes].
Folia Haematol Int Mag Klin Morphol Blutforsch. 1961;78:436-40.
5
Polysaccharides in the different stages of the life-cycles of certain sporozoa.
Parasitology. 1960 Nov;50:509-14. doi: 10.1017/s0031182000025580.
6
[A study of the citric acid cycle in erythrocytes].[红细胞中柠檬酸循环的研究]
J Biol Chem. 1958 Apr;231(2):913-24.
7
The inhibitory action of some antimalarial drugs and related compounds on the hexokinase of yeast and of Plasmodium berghei.某些抗疟药物及相关化合物对酵母和伯氏疟原虫己糖激酶的抑制作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):16-23. doi: 10.1111/j.1476-5381.1957.tb01355.x.
8
The in vitro respiratory metabolism of erythrocytic forms of Plasmodium berghei.
Exp Parasitol. 1956 Jan;5(1):59-78. doi: 10.1016/0014-4894(56)90006-6.
9
Glucose consumption of Plasmodium hexamerium.六核疟原虫的葡萄糖消耗
J Parasitol. 1955 Dec;41(6):595-603.
10
A cytochemical study of Plasmodium berghei Vincke and Lips, 1948.1948年伯氏疟原虫（温克和利普斯）的细胞化学研究
Ann Trop Med Parasitol. 1955 Oct;49(3):273-7. doi: 10.1080/00034983.1955.11685675.
Zotero 插件