Floridi A, Paggi M G, Marcante M L, Silvestrini B, Caputo A, De Martino C
J Natl Cancer Inst. 1981 Mar;66(3):497-9.
The action of Lonidamine [1-(2,4-chlorobenzyl)-1H-indazol-3-carboxylic acid] on respiration and aerobic lactate production of several murine tumor cells and normal differentiated murine cells was investigated. Lonidamine reduced the oxygen consumption in both normal and neoplastic cells. In contrast, it increased the aerobic glycolysis of normal cells but inhibited that of tumor cells. This selective action might be ascribed to the inhibition of mitochondrially bound hexokinase, which is usually absent in normal differentiated cells.
研究了氯尼达明[1-(2,4-二氯苄基)-1H-吲唑-3-羧酸]对几种小鼠肿瘤细胞和正常分化小鼠细胞呼吸及有氧乳酸生成的作用。氯尼达明降低了正常细胞和肿瘤细胞的耗氧量。相反，它增加了正常细胞的有氧糖酵解，但抑制了肿瘤细胞的有氧糖酵解。这种选择性作用可能归因于对线粒体结合型己糖激酶的抑制，而这种酶在正常分化细胞中通常不存在。
