Vergani C, Trovato G, Pietrogrande M, Crocchiolo P, Dioguardi N
Minerva Med. 1978 Jun 23;69(31):2081-94.
Serum total lipids, lipoprotein cholesterol, apolipoprotein A (Apo A) and liver function parameters have been investigated in patients with acute viral hepatitis and chronic liver disease. Hypertriglyceridaemia, absence of alpha and pre beta bands on the lipoprotein electrophoresis pattern, low level of Apo A, presence of abnormal lipoproteins (beta-VLDL and beta2-LP) were observed in the early phase of acute hepatitis. A positive correlation was found between Apo A and triglyceride bile acids, log total bilirubin, log SGPT. Lipoprotein abnormalities are probably due to low lecitin-cholesterol aciltransferasi activity. The reappearance of alpha lipoprotein and the increase of Apo A are sensitive indices of improvement of liver function. In chronic liver disease the levels of cholesterol and Apo A correlate with changes in the hepatocellular function.
对急性病毒性肝炎和慢性肝病患者的血清总脂质、脂蛋白胆固醇、载脂蛋白A（Apo A）和肝功能参数进行了研究。在急性肝炎早期观察到高甘油三酯血症、脂蛋白电泳图谱上α和前β带缺失、Apo A水平低、存在异常脂蛋白（β-VLDL和β2-LP）。发现Apo A与甘油三酯胆汁酸、对数总胆红素、对数谷丙转氨酶之间呈正相关。脂蛋白异常可能是由于卵磷脂胆固醇酰基转移酶活性低所致。α脂蛋白的重新出现和Apo A的增加是肝功能改善的敏感指标。在慢性肝病中，胆固醇和Apo A的水平与肝细胞功能的变化相关。
