乙型肝炎病毒介导的培养肝癌细胞中载脂蛋白mRNA丰度的变化。
Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.
作者信息
Norton Pamela A, Gong Qiaoke, Mehta Anand S, Lu Xuanyong, Block Timothy M
机构信息
Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania, USA.
出版信息
J Virol. 2003 May;77(9):5503-6. doi: 10.1128/jvi.77.9.5503-5506.2003.
Abstract
An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.
摘要
在两种肝癌细胞系中观察到乙肝病毒（HBV）与载脂蛋白AI和CIII mRNA的稳态水平之间呈负相关。对含有可诱导病毒基因组的第三种细胞系的分析表明，病毒前基因组RNA与载脂蛋白mRNA的减少有关。我们得出结论，尽管没有明显的细胞致病性，但HBV会改变受感染的细胞。
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