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Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.乙型肝炎病毒介导的培养肝癌细胞中载脂蛋白mRNA丰度的变化。
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Changes in the concentration and composition of plasma lipoproteins during the acute phase response.急性期反应期间血浆脂蛋白浓度和组成的变化。
Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):153-8. doi: 10.1097/00075197-200203000-00006.
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Transcriptional regulatory mechanisms of the human apolipoprotein genes in vitro and in vivo.人载脂蛋白基因在体外和体内的转录调控机制
Curr Opin Lipidol. 2001 Apr;12(2):181-207. doi: 10.1097/00041433-200104000-00012.
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Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).乙型肝炎病毒（HBV）相关肝细胞癌（HCC）发生发展的分子基础。
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Hepatitis B virus biology.乙型肝炎病毒生物学
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Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication.人乙型肝炎病毒（HBV）在稳定转染的肝癌细胞中的诱导表达：一种筛选HBV复制潜在抑制剂的新系统。
Antimicrob Agents Chemother. 1997 Aug;41(8):1715-20. doi: 10.1128/AAC.41.8.1715.
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Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma.乙型肝炎病毒X抗原在慢性感染发病机制及肝细胞癌发生发展中的作用
Am J Pathol. 1997 Apr;150(4):1141-57.
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Characterization of mouse fibronectin alternative mRNAs reveals an unusual isoform present transiently during liver development.小鼠纤连蛋白可变mRNA的特征分析揭示了肝脏发育过程中短暂出现的一种异常异构体。
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Prolonged infection with hepatitis B virus and association between low blood cholesterol concentration and liver cancer.乙型肝炎病毒的长期感染以及低血胆固醇浓度与肝癌之间的关联。
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Hepatitis B virus immunopathogenesis.乙型肝炎病毒免疫发病机制
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High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules.高密度脂蛋白抑制细胞因子诱导的内皮细胞黏附分子表达。
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乙型肝炎病毒介导的培养肝癌细胞中载脂蛋白mRNA丰度的变化。

Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.

作者信息

Norton Pamela A, Gong Qiaoke, Mehta Anand S, Lu Xuanyong, Block Timothy M

机构信息

Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania, USA.

出版信息

J Virol. 2003 May;77(9):5503-6. doi: 10.1128/jvi.77.9.5503-5506.2003.

DOI:10.1128/jvi.77.9.5503-5506.2003
PMID:12692252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153946/
Abstract

An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.

摘要

在两种肝癌细胞系中观察到乙肝病毒（HBV）与载脂蛋白AI和CIII mRNA的稳态水平之间呈负相关。对含有可诱导病毒基因组的第三种细胞系的分析表明，病毒前基因组RNA与载脂蛋白mRNA的减少有关。我们得出结论，尽管没有明显的细胞致病性，但HBV会改变受感染的细胞。