Iyenegar B
Acta Morphol Acad Sci Hung. 1976;24(1-2):161-71.
Copper sulphate, phenyl hydrazine and antiserum were administered to adult albino rats to produce equivalent haemolysis. Red pulp activity was studied for myeloid metaplasia after 24, 48 and 72 h, 5 and 7 days. Myeloid metaplasia was not related to the marginal zone proliferation. The activity rose rapidly with all the three agents and followed a similar curve despite the different patterns of haemolysis and erythrophagocytosis. Splenic erythrophagocytosis acts as a powerful feedback for splenic myeloid metaplasia. With copper, the release of reticulocytes and iron binding in haemoglobin is rapid as compared to the other agents, in spite of the initial lag phase, due to its effect on cellular metabolism.
给成年白化大鼠注射硫酸铜、苯肼和抗血清以产生等量溶血。在24、48和72小时、5天和7天后研究红髓活性以观察髓样化生情况。髓样化生与边缘区增殖无关。尽管溶血和红细胞吞噬模式不同，但这三种试剂均可使活性迅速升高且遵循相似曲线。脾红细胞吞噬作用是脾髓样化生的有力反馈。与其他试剂相比，铜对细胞代谢有影响，尽管有初始延迟期，但与血红蛋白结合的网织红细胞释放和铁释放迅速。
