伴有IgE M成分的华氏巨球蛋白血症

Waldenström's macroglobulinaemia with Ig E M-component.

作者信息

Shirakura T, Takekoshi K, Umi M, Kanazawa K, Okabe H, Inoue T, Imamura Y

出版信息

Scand J Haematol. 1978 Oct;21(4):292-8. doi: 10.1111/j.1600-0609.1978.tb00367.x.

DOI:10.1111/j.1600-0609.1978.tb00367.x

Abstract

A case of Waldenström's macroglobulinaemia with Ig E M-component was presented. A 76-year-old Japanese woman had a history of the operation for mammary carcinoma. Although neither lymphadenopathy nor hepatosplenomegaly was present, the immunohaematological findings typical for Waldenström's macroglobulinaemia were observed in this patient. Coexistence of the Ig M and Ig E M-components was recognized in the patient's serum protein. Positive reaction for FITC-conjugated anti-epsilon or rhodamine-conjugated anti-mu was noted in proliferating lymphoplasmacytic cells of the patient's bone marrow, but these reactions were not simultaneously observed in a single cell. The finding suggests that two separate populations of M-component-producing cells were present.

摘要

报告了1例伴有IgE M成分的华氏巨球蛋白血症。一名76岁的日本女性有乳腺癌手术史。该患者虽无淋巴结病和肝脾肿大，但出现了华氏巨球蛋白血症典型的免疫血液学表现。患者血清蛋白中IgM和IgE M成分并存。在患者骨髓增殖性淋巴浆细胞中，观察到异硫氰酸荧光素（FITC）标记的抗ε或罗丹明标记的抗μ呈阳性反应，但在单个细胞中未同时观察到这些反应。这一发现提示存在两个产生M成分的独立细胞群。