肢端肥大症患者血清中糖蛋白激素的α亚基及其肿瘤中的mRNA

Alpha subunit of glycoprotein hormones in the sera of acromegalic patients and its mRNA in the tumors.

作者信息

Machiavelli G A, Artese R, Benencia H, Bruno O, Guerra L, Basso A, Burdman J A

机构信息

Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.

出版信息

Neurol Res. 1999 Apr;21(3):247-9. doi: 10.1080/01616412.1999.11740926.

DOI:10.1080/01616412.1999.11740926

PMID:10319331

Abstract

Within a population of 16 pituitary adenomas we found high levels of glycoprotein alpha subunits in the sera of patients with somatotrophic tumors. This finding was correlated with the presence of mRNA alpha subunit in these tumors indicating the adenomas themselves as the origin of the circulating alpha-subunit. Synthesis of these two hormones, which are chemically very different, by the same tumor cells indicates a high degree of differentiation of these cells. We are unable at this time to conclusively correlate differentiation of these tumors aggressively.

摘要

在16例垂体腺瘤患者群体中，我们发现生长激素瘤患者血清中糖蛋白α亚基水平较高。这一发现与这些肿瘤中α亚基mRNA的存在相关，表明腺瘤本身是循环α亚基的来源。同一肿瘤细胞合成这两种化学性质差异很大的激素，表明这些细胞具有高度分化。目前我们无法确凿地将这些肿瘤的分化与侵袭性相关联。