Okumura A, Takenaka K, Nishimura Y, Asano Y, Sakai N, Kuwata K, Era S
Department of Neurosurgery, Gifu University School of Medicine, Japan.
Neurol Res. 1999 Apr;21(3):250-4. doi: 10.1080/01616412.1999.11740927.
The clinical applicability of magnetization transfer (MT) technique in magnetic resonance imaging (MRI) for the estimation of the histological and constitutional feature of brain tumors was investigated. MT effect was evaluated by measuring the MT ratio (MTR). The parameters in 1.5-tesla MRI system were as follows: TR, 50 msec; TE, 5 msec; flip angle, 30 degree; offset frequency of off-resonance MT pulse, 1000 Hz. The sequence was performed in 20 normal volunteers and 45 patients with brain tumors which were characterized histologically and surgically. The MTR for brain tumors was significantly lower than that for normal brain tissue (p < 0.05). The MTR for meningioma was higher than that for the other brain tumors (p < 0.05). In the meningiomas, MTR for fibrous type was higher than that for meningothelial type, but there was no statistical significance. Regarding the physical consistency for the brain tumors, as classified by surgery, there was a statistically significant difference in MTR between the soft tumor group (0.22 +/- 0.03, n = 6) and the hard tumor group (0.36 +/- 0.04, n = 10) (p < 0.01). This study suggested that the MT technique for patients with brain tumor may be useful to understand the characteristics of the tumors presurgically, based on the degree of intermolecular interaction of macromolecule such as protein.
研究了磁共振成像（MRI）中的磁化传递（MT）技术在评估脑肿瘤组织学和结构特征方面的临床适用性。通过测量MT比率（MTR）来评估MT效应。1.5特斯拉MRI系统的参数如下：重复时间（TR），50毫秒；回波时间（TE），5毫秒；翻转角，30度；非共振MT脉冲的偏置频率，1000赫兹。对20名正常志愿者和45例经组织学和手术确诊的脑肿瘤患者进行了该序列检查。脑肿瘤的MTR显著低于正常脑组织（p<0.05）。脑膜瘤的MTR高于其他脑肿瘤（p<0.05）。在脑膜瘤中，纤维型的MTR高于脑膜内皮型，但无统计学意义。关于手术分类的脑肿瘤的物理质地，软肿瘤组（0.22±0.03，n = 6）和硬肿瘤组（0.36±0.04，n = 10）的MTR存在统计学显著差异（p<0.01）。本研究表明，基于蛋白质等大分子的分子间相互作用程度，脑肿瘤患者的MT技术可能有助于术前了解肿瘤的特征。
