Watanabe A, Saito S, Tsuchida T, Higuchi K, Okita M
3rd Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Nutrition. 1999 Apr;15(4):284-8. doi: 10.1016/s0899-9007(99)00004-0.
Plasma levels of docosahexaenoic acid (DHA, C22:6 omega 3) were found to be decreased in 11 patients with alcoholic and non-alcoholic liver cirrhosis depending on the severity of liver damage. In this reduction, we found impaired metabolism of omega-3 long-chain polyunsaturated fatty acids in the cirrhotic liver and poor dietary intake of DHA to involved in the reduction of DHA plasma levels. The deficiency of this fatty acid, which is concentrated in the nervous tissues, may be related to the impaired neural function observed in hepatic encephalopathy of these patients. Oral DHA supplementation was supplied in the form of a polyunsaturated fatty acid-enriched soft oil capsule (omega 3/omega 6 ratio = 0.91, and P/S ratio = 1.87). Twelve capsules per day (containing 408 mg DHA, which corresponds to one-fourth of the DHA content in a normal daily diet) improved the DHA contents in the plasma phospholipid fractions of 5 alcoholic patients with low DHA levels.
根据肝损伤的严重程度，研究发现11例酒精性和非酒精性肝硬化患者的血浆二十二碳六烯酸（DHA，C22:6 ω-3）水平降低。在这种降低中，我们发现肝硬化肝脏中ω-3长链多不饱和脂肪酸代谢受损以及DHA的膳食摄入量低与DHA血浆水平降低有关。这种集中在神经组织中的脂肪酸缺乏可能与这些患者肝性脑病中观察到的神经功能受损有关。口服DHA补充剂以富含多不饱和脂肪酸的软胶囊形式提供（ω-3/ω-6比例=0.91，P/S比例=1.87）。每天服用12粒胶囊（含408 mg DHA，相当于正常每日饮食中DHA含量的四分之一）可提高5例DHA水平低的酒精性患者血浆磷脂组分中的DHA含量。
