Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, 11129 Belgrade, PO BOX 102, Serbia.
J Clin Biochem Nutr. 2013 Jul;53(1):49-54. doi: 10.3164/jcbn.12-79. Epub 2013 Jun 7.
The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty acids than healthy subjects. Total n-6 and n-3 polyunsaturated fatty acids (PUFA), and levels of linoleic, dihomo-gama linolenic, arachidonic, and docosahexaenoic acid were significantly lower (p<0.001) in patients with alcoholic cirrhosis compared to healthy controls. Significant changes were also found between patients stratified according to nutritional status. In particular, the sum of n-3 PUFA was significantly lower (p<0.001) and ratio of n-6/n-3 fatty acids was higher (p<0.01) in malnourished patients when compared to the patients with acceptable nutritional status. Furthermore, important changes in the levels of saturated fatty acids, palmitoleic and oleic acid and long-chain PUFA were found in well-nourished patients with alcoholic cirrhosis as well. Our present data confirmed evidence that malnutrition is one of the factors that led to lower levels of polyunsaturated fatty acids in patients with alcoholic liver cirrhosis. PUFA supplementation in the latter needs further investigation.
我们分析了 20 例酒精性肝硬化患者（11 例营养不良，9 例营养状况可）血清磷脂的脂肪酸组成；并以 25 例年龄和性别匹配的健康成年人作为对照。与健康受试者相比，肝硬化患者的棕榈酸和总饱和脂肪酸水平更高。与健康对照组相比，酒精性肝硬化患者的总 n-6 和 n-3 多不饱和脂肪酸（PUFA）以及亚油酸、二高-γ-亚麻酸、花生四烯酸和二十二碳六烯酸水平显著降低（p<0.001）。根据营养状况对患者进行分层后也发现了显著变化。特别是与营养状况可的患者相比，营养不良患者的 n-3 PUFA 总和显著降低（p<0.001），n-6/n-3 脂肪酸比值更高（p<0.01）。此外，在营养良好的酒精性肝硬化患者中，饱和脂肪酸、棕榈油酸和油酸以及长链 PUFA 的水平也发生了重要变化。我们目前的数据证实了营养不良是导致酒精性肝硬化患者多不饱和脂肪酸水平降低的因素之一。需要进一步研究后者的 PUFA 补充。
